Benzyl Chloride → 4-Benzyloxy-3-methoxy-benzonitrile

HRID 1072412ノート

反応式

HRID 1072412 の反応式
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[O:10][CH3:11].C([O-])([O-])=O.[K+].[K+].[CH2:18](Cl)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>CC(C)=O>[CH2:18]([O:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[O:10][CH3:11])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

5

反応物 3

HCID 7503Benzyl ChlorideHCID 11430Potassium CarbonateHCID 781354-Hydroxy-3-methoxybenzonitrile

生成物 1

HCID 7937714-Benzyloxy-3-methoxy-benzonitrile収率 88.9%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To 4-hydroxy-3-methoxybenzonitrile (20.0 g, 134 mmol) in acetone (200 ml) were added K2CO3 (55.6 g, 402 mmol) and benzyl chloride (23.2 ml, 201 mmol). The resulting reaction mixture was refluxed overnight. After cooling to room temperature, acetone was removed by evaporation under reduced pressure and the residue was recrystallized to obtain 4-benzyloxy-3-methoxy-benzonitrile(28.5 g, 88%). Then, according to the similar procedure of Example 1, 7-(4-Benzyloxy-3-methoxy-phenyl)-5-ethylsulfanyl-imidazo[1,2-c]pyrimidine was prepared.

後処理

  1. customThe resulting reaction mixture
  2. temperaturewas refluxed overnight
  3. customacetone was removed by evaporation under reduced pressure
  4. customthe residue was recrystallized

出典と根拠

ORDレコード
ord-3a7adb79b0ed4d3c9ff73eb4e56fd08e
出典データセット
uspto-grants-2005_06
特許番号
US06911443B2

反応ノート

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