HCID 178436619、化合物 → HCID 86590098、化合物

HRID 1072645ノート

反応式

HRID 1072645 の反応式
CC[C:3]1[C:7](=[O:8])[N:6]([C:9]([NH:11]CCC2C=CC(S(NC(N[C@@H]3CC[C@@H](C)CC3)=O)(=O)=O)=CC=2)=[O:10])[CH2:5][C:4]=1C>C1(C)C=CC=CC=1>[O:8]=[C:7]1[CH2:3][CH:4]=[CH:5][N:6]1[C:9]([NH2:11])=[O:10]

参加物

3

反応物 1

HCID 178436619HCID 178436619、化合物

生成物 1

HCID 86590098HCID 86590098、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a solution of glimepiride in dry toluene was added dropwise polytetrafluoroethyleneoxide-co-difluoromethyleneoxide-α,ω-diisocyanate (Mw ˜2,000, 0.2 equivalents) at ambient temperature. The reaction mixture was stirred for 2 hours, concentrated and then added to acetone. The resulting white solid was washed with ether and dried, yielding perfluoropolymer-labeled 3-ethyl-2,5-dihydro-4-methyl-N-[2{4-[[[(trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide.

後処理

  1. concentrationconcentrated
  2. additionadded to acetone
  3. washThe resulting white solid was washed with ether
  4. customdried

出典と根拠

ORDレコード
ord-a5d3920944aa419eab15d18100ccbb3b
出典データセット
uspto-grants-2005_06
特許番号
US06911457B2

反応ノート

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