Hydrochloric Acid → HCID 10255676、化合物

HRID 1072776ノート

反応式

HRID 1072776 の反応式
C[C@@H](N)C1C=CC=CC=1.C[C@@H](N)C1C=CC=CC=1.[N+:19]([CH2:22][C@:23]1([CH2:30][C:31]([OH:33])=[O:32])[CH2:29][C@@H:28]2[C@H:24]1[CH2:25][CH2:26][CH2:27]2)([O-:21])=[O:20].Cl>C(OCC)(=O)C>[N+:19]([CH2:22][C@:23]1([CH2:30][C:31]([OH:33])=[O:32])[CH2:29][C@@H:28]2[C@H:24]1[CH2:25][CH2:26][CH2:27]2)([O-:21])=[O:20]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 6431891-Phenethylamine, (+)-HCID 10449552HCID 10449552、化合物

生成物 1

HCID 10255676HCID 10255676、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

The (R)-α-methylbenzylamine salt of the nitro acid from example 2 (5.0 g, 23.4 mmol) was added to a mixture of ethyl acetate (50 ml) and 2M hydrochloric acid (15 ml). The mixture was stirred vigorously for 3-4 minutes and the phases were separated. The organic layer was further washed with 2M hydrochloric acid (15 ml) and demineralised water (15 ml). The organic layer was separated and the solvent was removed in vacuo to give the title compound as a yellow oil, which rapidly crystallised on standing (3.49 g).

後処理

  1. customthe phases were separated
  2. washThe organic layer was further washed with 2M hydrochloric acid (15 ml) and demineralised water (15 ml)
  3. customThe organic layer was separated
  4. customthe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-aa8c84ad00e142e4a0e8adf34372da1a
出典データセット
uspto-grants-2005_06
特許番号
US06911555B2

反応ノート

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