Hydrochloric Acid → 2,6-Difluoropyridine-4-carboxylic acid
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([F:12])[N:11]=1)[C:5]([O:7]C)=[O:6].Cl.O>O1CCOCC1>[F:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([F:12])[N:11]=1)[C:5]([OH:7])=[O:6]参加物
5
実験手順
22.6 g of methyl 2,6-difluoroisonicotinate are dissolved in 25 ml of dioxane and added to a mixture of 150 ml of conc. hydrochloric acid and 100 ml of water. The mixture is then refluxed for 21/4 hours, volume is reduced to about 5/8 by evaporation, and the residue is cooled. The acid which precipitates out in crystalline form is filtered off and dried.
後処理
- temperatureThe mixture is then refluxed for 21/4 hours, volume
- customis reduced to about 5/8 by evaporation
- temperaturethe residue is cooled
- customThe acid which precipitates out in crystalline form
- filtrationis filtered off
- customdried
出典と根拠
- ORDレコード
- ord-5ae4271cc7f2404bb6cb5d5787bffebb
- 出典データセット
- uspto-grants-1990_11
- 特許番号
- US04968344
反応ノート
読み込み中…