化工社化工社 化学情報印刷レポート · 研究参考用
Hydrazine hydrate (1:1) → Quinuclidine-3-carbohydrazide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | Methyl quinuclidine-3-carboxylate | HCID 2736953 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Potassium Carbonate | HCID 11430 | — |
| 生成物 | Quinuclidine-3-carbohydrazide | HCID 573413 | 100% |
反応手順
(±) Methyl 1-azabicyclo[2.2.2]octane-3-carboxylate* (0.36 g; 2.1 mmoles) and hydrazine hydrate (0.35 ml; 7.0 mmoles) were heated at 120° C. for 2 h. The reaction was diluted with water (10 ml), saturated with potassium carbonate and extracted into chloroform (3×15 ml). Combined organic extracts were dried (Na2SO4) and concentrated to give the title compound as a pale oil (0.36 g; 100%) which was used in the next stage without further purification. *
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04968691 |
| 出典データセット | uspto-grants-1990_11 |
| ORD ID | ord-0f50e22830d14977ab82e6f434ef78a4 |
| 出典メモ | uspto-grants-1990_11 |