(3-Butoxyphenyl)acetonitrile → HCID 22379525、化合物

HRID 1073242ノート

反応式

HRID 1073242 の反応式
[CH2:1]([O:5][C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][CH:14]=1)[CH2:9][C:10]#[N:11])[CH2:2][CH2:3][CH3:4].[H][H]>[Ni].CO>[CH2:1]([O:5][C:6]1[CH:7]=[C:8]([CH2:9][CH2:10][NH2:11])[CH:12]=[CH:13][CH:14]=1)[CH2:2][CH2:3][CH3:4]

参加物

5

反応物 2

HCID 22158212(3-Butoxyphenyl)acetonitrileHCID 178418361HCID 178418361、化合物

生成物 1

HCID 22379525HCID 22379525、化合物収率 106.9%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

Raney nickel catalyst (approx 5 g) was added to a solution of 3-butyloxybenzyl cyanide (38.64 g, prepared according to example 1 D) in saturated ammoniacal methanol (700 cm3). The resulting mixture was heated at 70° C. in the presence of hydrogen (45 Atmospheres) for two hours and was then allowed to cool to room temperature overnight. The cooled mixture was filtered to remove the catalyst and was then evaporated down to give a green oil (42.2 g).

後処理

  1. filtrationThe cooled mixture was filtered
  2. customto remove the catalyst
  3. customwas then evaporated down

出典と根拠

ORDレコード
ord-7253f6f586a5486c800e761f8ff6ab2a
出典データセット
uspto-grants-1990_11
特許番号
US04968698

反応ノート

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