3-Aminopyrrolidine → HCID 18640048、化合物

HRID 1073311ノート

反応式

HRID 1073311 の反応式
[Cl-:1].[K+].[Pt+2:3].[Cl-:4].[Cl-].[NH2:6][CH:7]1[CH2:11][CH2:10][NH:9][CH2:8]1>O>[Pt+2:3].[Cl:1][C@H:8]1[C@@H:7]([NH2:6])[CH2:11][CH2:10][N:9]1[Cl:4]

参加物

4

反応物 2

HCID 1644013-AminopyrrolidineHCID 86744074platinum (II) potassium chloride

生成物 1

HCID 18640048HCID 18640048、化合物収率 67.9%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of platinum (II) potassium chloride (12.2 g) in water (800 ml) is added (3RS)-3-aminopyrrolidine (2.5 g), and the mixture is stirred at room temperature for 19 hours. The precipitated solid is removed by filtration, and the filtrate is concentrated under reduced pressure. To the residue is added a small amount of water, and the resulting crystals are separated by filtration and washed with water and acetone to give cis-dichloro-(3RS)-3-aminopyrrolidine platinum (II) (6.9 g) as pale yellow crystal.

後処理

  1. customThe precipitated solid is removed by filtration
  2. concentrationthe filtrate is concentrated under reduced pressure
  3. additionTo the residue is added a small amount of water
  4. customthe resulting crystals are separated by filtration
  5. washwashed with water and acetone

出典と根拠

ORDレコード
ord-d31b2055efa54c618585d4f5e5009d7a
出典データセット
uspto-grants-1990_11
特許番号
US04968800

反応ノート

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