Ethyl 4-chloro-3-ethyl-1-methyl-1H-pyrazole-5-carboxylate → HCID 14771162、化合物
反応式
[Cl:1][C:2]1[C:3]([CH2:13][CH3:14])=[N:4][N:5]([CH3:12])[C:6]=1[C:7]([O:9]CC)=O.[NH2:15][CH2:16][C:17]1[CH:18]=[CH:19][C:20]([CH2:23][CH2:24][CH2:25][CH3:26])=[N:21][CH:22]=1>>[CH2:23]([C:20]1[N:21]=[CH:22][C:17]([CH2:16][NH:15][C:7]([C:6]2[N:5]([CH3:12])[N:4]=[C:3]([CH2:13][CH3:14])[C:2]=2[Cl:1])=[O:9])=[CH:18][CH:19]=1)[CH2:24][CH2:25][CH3:26]参加物
3
反応条件
- 温度
- 200 °C
実験手順
A mixture of 2.17 g of ethyl 4-chloro-3-ethyl-1-methylpyrazole-5-carboxylate and 3.24 g of 5-aminomethyl-2-n-butylpyridine was heated at 200° C. for 4 hours under stirring. After cooling to room temperature, the reaction mixture was purified by silica gel columnchromatography to obtain 2.06 g of the compound (NO. 15) listed in Table 1.
後処理
- temperatureAfter cooling to room temperature
- customthe reaction mixture was purified by silica gel columnchromatography