Propylene Oxide → HCID 10802942、化合物

HRID 1073364ノート

反応式

HRID 1073364 の反応式
[O:1]1[CH:3]([CH3:4])[CH2:2]1.[CH3:5][NH:6][CH2:7][CH2:8][CH:9]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>CO>[CH3:5][N:6]([CH2:7][CH2:8][CH:9]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[CH2:2][CH:3]([OH:1])[CH3:4]

参加物

4

反応物 2

HCID 6378Propylene Oxide2 回HCID 119812N-Methyl-gamma-phenylbenzenepropanamine

生成物 1

HCID 10802942HCID 10802942、化合物収率 84.8%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

6.38 g of 1,2-epoxypropane was added to a solution of 22.5 g of N-methyl-3,3-diphenylpropylamine in 60 ml of methanol. The solution was maintained at 15°-20° C. for 3 days, and then an additional 1.16 g of 1,2-epoxypropane was added. This solution was maintained for 24 hours at room temperature. The methanol was evaporated off and the product purified by chromatography on a silica gel column (methanol gradient in chloroform), to give 24 g of the title compound as colorless oil.

後処理

  1. temperatureThe solution was maintained at 15°-20° C. for 3 days
  2. customThe methanol was evaporated off
  3. customthe product purified by chromatography on a silica gel column (methanol gradient in chloroform)

出典と根拠

ORDレコード
ord-687a147fd076481199c323ed973f1865
出典データセット
uspto-grants-1990_11
特許番号
US04968832

反応ノート

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