1-O-hexadecyl-2-O-methylglycerol → 3-(Hexadecyloxy)-2-methoxypropyl phenyl phosphorochloridate

HRID 1073460

反応式

HRID 1073460 の反応式
[CH2:1]([O:17][CH2:18][CH:19]([O:22][CH3:23])[CH2:20][OH:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[P:24](Cl)([Cl:33])([O:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)=[O:25].ClCCl>C(N(CC)CC)C>[P:24]([Cl:33])(=[O:25])([O:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[O:21][CH2:20][CH:19]([O:22][CH3:23])[CH2:18][O:17][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

参加物

5

反応物 3

HCID 13801-O-hexadecyl-2-O-methylglycerolHCID 6344DichloromethaneHCID 13038Phosphorodichloridic acid, phenyl ester

生成物 1

HCID 221586273-(Hexadecyloxy)-2-methoxypropyl phenyl phosphorochloridate

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

反応条件

温度
5 °C

実験手順

A 1 mmol portion of 3-(hexadecyloxy)-2-methoxy propanol is added to a 0°-5° C. solution of 1 mmol of phenyl dichlorophosphate in 2 ml of anhydrous dichloromethane containing 1.2 mmol of triethylamine. The mixture is stirred under argon for 1 hour at 5° C., then for 2.5 hours at room temperature and then used as is.

後処理

  1. waitfor 2.5 hours at room temperature

出典と根拠

ORDレコード
ord-2c6ff3b38cb74657812fe94e3396e1f8
出典データセット
uspto-grants-1990_11
特許番号
US04968790

関連ノート

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