Sulfuric Acid → 5-(2-Bromophenyl)-5-oxovaleric acid

HRID 1073565ノート

反応式

HRID 1073565 の反応式
[OH:1]S(O)(=O)=O.[Br:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]#[C:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18]>O>[Br:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13](=[O:1])[CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18]

参加物

4

反応物 2

HCID 1118Sulfuric AcidHCID 147984675-(2-Bromophenyl)-4-pentynoic acid

生成物 1

HCID 147984685-(2-Bromophenyl)-5-oxovaleric acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
0 °C

実験手順

Into 20 cc of concentrated H2SO4 was dissolved 0.1 g (0.4 mmol) of the product of Example 1 to give a brown solution. The solution was allowed to stand at room temperature for 10 minutes. Thereafter, the solution was cooled to 0° C. in an ice bath and ice was then added to it. The solution was then diluted with water and extracted twice with ethyl acetate. The combined extracts were sequentially washed once each with water and brine and then dried (MgSO4). Removal of the solvent under reduced pressure produced a yellow oil which was used without further purification.

後処理

  1. customto give a brown solution
  2. additionice was then added to it
  3. extractionextracted twice with ethyl acetate
  4. washThe combined extracts were sequentially washed once each with water and brine
  5. dry with materialdried (MgSO4)
  6. customRemoval of the solvent under reduced pressure
  7. customproduced a yellow oil which
  8. customwas used without further purification

出典と根拠

ORDレコード
ord-17f6c2f7fdb64bccb2cae6bc2ff459f0
出典データセット
uspto-grants-1990_11
特許番号
US04970229

反応ノート

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