Potassium Hydroxide → 3-[3-(Cyclopentyloxy)-4-methoxyphenyl]acrylic acid

HRID 1073750ノート

反応式

HRID 1073750 の反応式
[CH:1]1([O:6][C:7]2[CH:8]=[C:9](/[CH:15]=[CH:16]/[C:17]([O:19]C)=[O:18])[CH:10]=[CH:11][C:12]=2[O:13][CH3:14])[CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[K+]>CO.O>[CH:1]1([O:6][C:7]2[CH:8]=[C:9](/[CH:15]=[CH:16]/[C:17]([OH:19])=[O:18])[CH:10]=[CH:11][C:12]=2[O:13][CH3:14])[CH2:2][CH2:3][CH2:4][CH2:5]1

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 5702848methyl 3-(3-cyclopentoxy-4-methoxyphenyl)-E-propenoate

生成物 1

HCID 57121053-[3-(Cyclopentyloxy)-4-methoxyphenyl]acrylic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

To a stirring solution of 0.8 g (2.9 mmol) of methyl 3-(3-cyclopentoxy-4-methoxyphenyl)-E-propenoate in 20 mL of methanol was added dropwise 25 mL of a 1.0 N solution of potassium hydroxide in water over a 5 minute period. The mixture precipitated immediately, but returned to a solution after a 16-hour period at which time the solution was concentrated, diluted with 20 mL of water and neutralized to pH 1.0 with concentrated hydrochloric acid. The analytically pure white solid which formed was collected, washed several times with cold water, and dried in vacuo.

後処理

  1. customThe mixture precipitated immediately
  2. waitreturned to a solution after a 16-hour period at which time
  3. concentrationthe solution was concentrated
  4. additiondiluted with 20 mL of water and neutralized to pH 1.0 with concentrated hydrochloric acid
  5. customThe analytically pure white solid which formed
  6. customwas collected
  7. washwashed several times with cold water
  8. customdried in vacuo

出典と根拠

ORDレコード
ord-51e25a6d680d42169ff68d870dc0f7b1
出典データセット
uspto-grants-1990_11
特許番号
US04971959

反応ノート

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