1-Cyclopropyl-6-fluoro-7-(4-formyl-3-methyl-1-piperazinyl)-5-methyl-4-oxo-3-formyl1,2,3,4-tetrahydroquinoline → 1-Cyclopropyl-6-fluoro-7-(4-formyl-3-methyl-1-piperazinyl)-5-methyl-3-formyl-1,4-dihydro-4oxoquinoline
反応式
[CH:1]1([N:4]2[C:13]3[C:8](=[C:9]([CH3:24])[C:10]([F:23])=[C:11]([N:14]4[CH2:19][CH2:18][N:17]([CH:20]=[O:21])[CH:16]([CH3:22])[CH2:15]4)[CH:12]=3)[C:7](=[O:25])[CH:6]([CH:26]=[O:27])[CH2:5]2)[CH2:3][CH2:2]1>CO.[O-2].[O-2].[Mn+4]>[CH:1]1([N:4]2[C:13]3[C:8](=[C:9]([CH3:24])[C:10]([F:23])=[C:11]([N:14]4[CH2:19][CH2:18][N:17]([CH:20]=[O:21])[CH:16]([CH3:22])[CH2:15]4)[CH:12]=3)[C:7](=[O:25])[C:6]([CH:26]=[O:27])=[CH:5]2)[CH2:3][CH2:2]1参加物
4
反応物 1
生成物 1
試薬・触媒・溶媒 2
実験手順
1-Cyclopropyl-6-fluoro-7-(4-formyl-3-methyl-1-piperazinyl)-5-methyl-4-oxo-3-formyl-1,2,3,4-tetrahydroquinoline (4.0 g) is dissolved in methanol (150 ml) and thereto is added manganese dioxide (9.3 g), and the mixture is stirred at room temperature for 2 hours. After removing manganese dioxide by filtration with celite, the filtrate is concentrated, and the resulting residue is recrystallized from ethanol to give 1-cyclopropyl-6-fluoro-7-(4-formyl-3 -methyl-1-piperazinyl)-5-methyl-3-formyl-1,4-dihydro-4oxoquinoline (3.9 g), as pale yellow powdery crystals, m.p. 258°-260° C.