Water → HCID 15079957、化合物
反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:9][CH3:10])=[C:6]([OH:8])[CH:7]=1.[CH2:11](Br)[CH2:12][Br:13].C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[Br:13][CH2:12][CH2:11][O:8][C:6]1[CH:7]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=1[O:9][CH3:10]参加物
6
反応条件
- 温度
- 80 °C
実験手順
A suspension of 10.0 g of 5-fluoro-2-methoxyphenol, 52.9 g of ethylenebromide and 14.6 g of potassium carbonate in 50 ml of N,N-dimethylformamide was heated for 11 hours at 80° C. After cooling, the reaction mixture was poured into water and extracted with ethyl acetate. The extract was washed with water, dried and evaporated. The residue was chromatographed on silica gel using 50% chloroform-n-hexane as an eluent to give 11.6 g of the desired compound as a colorless oil.
後処理
- temperatureAfter cooling
- extractionextracted with ethyl acetate
- washThe extract was washed with water
- customdried
- customevaporated
- customThe residue was chromatographed on silica gel using 50% chloroform-n-hexane as an eluent
出典と根拠
- ORDレコード
- ord-5139b037b59f44eda76046784919d94b
- 出典データセット
- uspto-grants-1990_11
- 特許番号
- US04971990
反応ノート
読み込み中…