Hydrochloric Acid → L-prolyl-L-proline benzylester hydrochloride
反応式
[CH2:1]([O:8][C:9](=[O:29])[C@@H:10]1[CH2:14][CH2:13][CH2:12][N:11]1[C:15](=[O:28])[C@@H:16]1[CH2:20][CH2:19][CH2:18][N:17]1C(OC(C)(C)C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:30]>O1CCOCC1>[ClH:30].[CH2:1]([O:8][C:9](=[O:29])[C@@H:10]1[CH2:14][CH2:13][CH2:12][N:11]1[C:15](=[O:28])[C@@H:16]1[CH2:20][CH2:19][CH2:18][NH:17]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
N-t-butyloxycarbonyl-L-prolyl-L-proline benzylester (60.70 g, 150 mmole) was dissolved in 4N hydrochloric acid in dioxane (350 ml) solution, and stirred for 1 hour at room temperature. The solution was concentrated under reduced pressure, and diethyl ether was added to the solution while cooling with ice and stirring to obtain L-prolyl-L-proline benzylester hydrochloride (47.80 g, 94.1%).