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Acetic acid, (phenylthio)-, ethyl ester → Ethyl 5-dimethylamino-5-phenyl-2-phenylthio-2,4-pentadienoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic acid, (phenylthio)-, ethyl ester | HCID 97312 | — |
| 反応物 | Sodium ethoxide | HCID 2723922 | — |
| 反応物 | N-(3-dimethylamino-3-phenylpropenylidene)-N-methylmethanaminium tetrafluoroborate | HCID 75556698 | — |
| 反応物 | Diethyl 2-dimethylamino-5-phenylthio-2,4-hexadienedioate | HCID 86743580 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Ethyl 5-dimethylamino-5-phenyl-2-phenylthio-2,4-pentadienoate | HCID 86743587 | — |
反応手順
The procedure is as in Example 2 for the preparation of diethyl 2-dimethylamino-5-phenylthio-2,4-hexadienedioate, starting with N-(3-dimethylamino-3-phenylpropenylidene)-N-methylmethanaminium tetrafluoroborate (15.4 g), a 2M solution of sodium ethylate (26.5 cc) and ethyl (phenylthio)acetate (10.4 g) in ethanol (150 cc). After purification by chromatography on a silica column with dichloromethane as eluent, ethyl 5-dimethylamino-5-phenyl-2-phenylthio-2,4-pentadienoate (9.7 g), m.p. 99° C., is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04971979 |
| 出典データセット | uspto-grants-1990_11 |
| ORD ID | ord-67777bd2097248d79bd645e6d60a632e |
| 出典メモ | uspto-grants-1990_11 |