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2-Chloro-3',4'-dihydroxyacetophenone → 3',4'-Dihydroxy-2-(methylthio)acetophenone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloro-3',4'-dihydroxyacetophenone | HCID 66834 | — |
| 反応物 | Sodium methanethiolate | HCID 4378561 | — |
| 反応物 | alpha-Methylthioacetophenone | HCID 18968240 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 3',4'-Dihydroxy-2-(methylthio)acetophenone | HCID 13718339 | — |
反応手順
The procedure is as in Example 4 for the preparation of α-methylthioacetophenone, starting with a stirred solution of 4-(2-chloroacetyl)pyrocatechol (18.6 g) in methanol (200 cc). Sodium methanethiolate (7 g) is added in the course of 15 minutes at a temperature in the region of 20° C., and the mixture is left with stirring for 3 hours at the same temperature. 4-[2-(Methylthio)acetyl]pyrocatechol (14.5 g), m.p. 107° C., is thereby obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04971979 |
| 出典データセット | uspto-grants-1990_11 |
| ORD ID | ord-745b1e2c84bc4c479404a27dd4b7b2fb |
| 出典メモ | uspto-grants-1990_11 |