Hexane → 1-(4-Chlorophenyl)-2-cyclopropylpropan-1-one

HRID 1074318ノート

反応式

HRID 1074318 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:14])[CH:9]([CH:11]2[CH2:13][CH2:12]2)[CH3:10])=[CH:4][CH:3]=1.C(N(CC)CC)C.CCCCCC>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[O:14])[CH:9]([CH:11]2[CH2:13][CH2:12]2)[CH3:10])=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 8058HexaneHCID 8471TriethylamineHCID 190783851-(4-Chlorophenyl)-2-cyclopropylpropan-1-ol

生成物 1

HCID 134886191-(4-Chlorophenyl)-2-cyclopropylpropan-1-one収率 86%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

After 15 minutes 1-(4-chlorophenyl)-2-cyclopropylpropan-1-ol (44.72 g, 212 mmol) in dry dichloromethane (330 ml) was added over approximately 35 minutes. After 75 minutes triethylamine (154 ml), 1105 mmol) was added and the mixture allowed to warm to room temperature. Hexane was added and the mixture washed with 1M hydrochloric acid, saturated aqueous sodium bicarbonate solution and water, dried and evaporated in vacuo. Chromatography [SiO2, hexane-ethyl acetate (100:0) to (90:10)] gave 1-(4-chlorophenyl)-2-cyclopropylpropan-1-one (38.0 g, 86%).

後処理

  1. washthe mixture washed with 1M hydrochloric acid, saturated aqueous sodium bicarbonate solution and water
  2. customdried
  3. customevaporated in vacuo

出典と根拠

ORDレコード
ord-c83872dbc42b4e8ab42ab55217af0e02
出典データセット
uspto-grants-1990_11
特許番号
US04973767

反応ノート

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