Hydrochloric Acid → 2-(2-Aminothiazol-4-yl)-2-cyclopropyloxyiminoacetic acid hydrochloride

HRID 1074347ノート

反応式

HRID 1074347 の反応式
[CH:1]1([O:4][N:5]=[C:6]([C:10]2[N:11]=[C:12]([NH:15]C=O)[S:13][CH:14]=2)[C:7]([OH:9])=[O:8])[CH2:3][CH2:2]1.[ClH:18]>CO>[ClH:18].[NH2:15][C:12]1[S:13][CH:14]=[C:10]([C:6](=[N:5][O:4][CH:1]2[CH2:3][CH2:2]2)[C:7]([OH:9])=[O:8])[N:11]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 540072742-Cyclopropyloxyimino-2-(2-formamidothiazol-4-yl)acetic acid

生成物 1

HCID 867443572-(2-Aminothiazol-4-yl)-2-cyclopropyloxyiminoacetic acid hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 2-cyclopropyloxyimino-2-(2-formamidothiazol-4-yl) acetic acid (syn isomer) (255 mg) and conc. hydrochloric acid (0.21 ml) in methanol (1.3 ml) was stirred at 30° to 32° C. for 1.5 hours. The mixture was concentrated in vacuo, triturated with diisopropyl ether, diethyl ether and ethyl acetate in turn. The resultant solid was dried over phosphorus pentoxide to give 2-(2-aminothiazol-4-yl)-2-cyclopropyloxyiminoacetic acid hydrochloride (syn isomer) (265 mg).

後処理

  1. concentrationThe mixture was concentrated in vacuo
  2. customtriturated with diisopropyl ether, diethyl ether and ethyl acetate in turn
  3. dry with materialThe resultant solid was dried over phosphorus pentoxide

出典と根拠

ORDレコード
ord-926525e67b2a4b009b8403c89e8d83ba
出典データセット
uspto-grants-1990_11
特許番号
US04973699

反応ノート

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