Hydrochloric Acid → Methyl 3-sulfamoyl-1-benzothiophene-2-carboxylate

HRID 1074373ノート

反応式

HRID 1074373 の反応式
C([NH:5][S:6]([C:9]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[S:11][C:10]=1[C:18]([O-:20])=[O:19])(=[O:8])=[O:7])(C)(C)C.Cl.[CH3:22]O>>[NH2:5][S:6]([C:9]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[S:11][C:10]=1[C:18]([O:20][CH3:22])=[O:19])(=[O:8])=[O:7]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 867389413-Tert-butylaminosulfonylbenzothiophene-2-carboxylate

生成物 1

HCID 13178321Methyl 3-sulfamoyl-1-benzothiophene-2-carboxylate

実験手順

A solution of 6 g of 3-tert-butylaminosulfonylbenzothiophene-2-carboxylate acid in 100 ml of methanol was saturated with anhydrous hydrogen chloride and then heated to reflux for three hours. The mixture was evaporated in vacuo to half of its volume and the residue poured into 200 g of ice and filtered to yield the desired product melting at 150°-154°. The infrared absorption spectrum shown by this material was qualitatively equivalent to that of the product of Example 4.

後処理

  1. temperatureheated
  2. temperatureto reflux for three hours
  3. customThe mixture was evaporated in vacuo to half of its volume
  4. additionthe residue poured into 200 g of ice
  5. filtrationfiltered

出典と根拠

ORDレコード
ord-e853363dd4d946f4908ab3b7e0dc3837
出典データセット
uspto-grants-1983_07
特許番号
US04391627

反応ノート

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