Piperidine → HCID 20496598、化合物

HRID 1074389ノート

反応式

HRID 1074389 の反応式
Cl[C:2]1[CH:14]=[CH:13][C:5]2=[N:6][C:7]3[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=3[N:4]2[N:3]=1.[NH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1>>[N:15]1([C:2]2[CH:14]=[CH:13][C:5]3=[N:6][C:7]4[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=4[N:4]3[N:3]=2)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1

参加物

3

反応物 2

HCID 8082PiperidineHCID 11148455HCID 11148455、化合物

生成物 1

HCID 20496598HCID 20496598、化合物

実験手順

A solution of 5.0 g of 2-chloro-6,7,8,9-tetrahydropyridazino[1,6-a]benzimidazole in 30 ml of piperidine was stirred and heated at reflux for 72 hours. The reaction mixture was poured into 200 ml of ice water and the tan solid which formed was separated by filtration and air dried. It was then recrystallized from a mixture of ethanol and water to give 2-(1-piperidinyl)-6,7,8,9-tetrahydropyridazino[1,6-a]benzimidazole melting at about 184°-185° C.

後処理

  1. temperatureheated
  2. temperatureat reflux for 72 hours
  3. customthe tan solid which formed
  4. customwas separated by filtration and air
  5. customdried
  6. customIt was then recrystallized from a mixture of ethanol and water

出典と根拠

ORDレコード
ord-85e88e01e10f4ea59afe1e3eb82b2c5d
出典データセット
uspto-grants-1983_07
特許番号
US04391806

反応ノート

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