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1,1-Diphenylacetone → 3-Diphenylmethyl-2,3,6,7,-tetrahydro-5H-thiazolo[3,2-a]pyrimidin-3-ol hydrobromide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,1-Diphenylacetone | HCID 69907 | — |
| 反応物 | Tetrahydropyrimidine-2-thione | HCID 2723785 | — |
| 反応物 | 3-Bromo-1,1-diphenylacetone | HCID 2794635 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 3-Diphenylmethyl-2,3,6,7,-tetrahydro-5H-thiazolo[3,2-a]pyrimidin-3-ol hydrobromide | HCID 20495713 | — |
反応手順
A 2.1 g. portion of 1,1-diphenyl-2-propanone is converted to 1-bromo-3,3-diphenyl-2-propanone by the procedure of Example 22. The 1-bromo-3,3-diphenyl-2-propanone is dissolved in 15 ml. of acetone and added to a boiling mixture of 0.80 g. of tetrahydro-2-pyrimidinethione in 70 ml. of acetone. This mixture is allowed to stand for 48 hours and the resulting solid is collected by filtration, giving the desired product, m.p. 196°-198° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04393004 |
| 出典データセット | uspto-grants-1983_07 |
| ORD ID | ord-efa704cb1c0d421ba273e5a225d15ade |
| 出典メモ | uspto-grants-1983_07 |