化工社化工社 化学情報印刷レポート · 研究参考用
1,1-Diphenylacetone → 3-Diphenylmethyl-2,3,6,7-tetrahydro-6,6-dimethyl-5H-thiazolo[3,2-a]pyrimidin-3-ol hydrobromide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,1-Diphenylacetone | HCID 69907 | — |
| 反応物 | 3-Bromo-1,1-diphenylacetone | HCID 2794635 | — |
| 反応物 | 5,5-Dimethyl-1,4,5,6-tetrahydro-pyrimidine-2-thiol | HCID 3866487 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 3-Diphenylmethyl-2,3,6,7-tetrahydro-6,6-dimethyl-5H-thiazolo[3,2-a]pyrimidin-3-ol hydrobromide | HCID 15571212 | — |
反応手順
A 2.1 g. portion of 1,1-diphenyl-2-propanone is converted to 1-bromo-3,3-diphenyl-2-propanone as described in Example 22. This 1-bromo-3,3-diphenyl-2-propanone is dissolved in 15 ml. of acetone and added to a boiling mixture of 1.0 g. of tetrahydro-5,5-dimethyl-2(1H)-pyrimidinethione in 50 ml. of acetone. The mixture is allowed to stand at room temperature for 24 hours and the resulting solid is collected by filtration, giving the desired product, m.p. 259°-261° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04393004 |
| 出典データセット | uspto-grants-1983_07 |
| ORD ID | ord-3130c19ef8eb4df6a7981fdcec590ce9 |
| 出典メモ | uspto-grants-1983_07 |