O-Xylene → HCID 178445521、化合物

HRID 1074591

反応式

HRID 1074591 の反応式
[CH2:1]([CH:4]1[CH2:9][C:8](=[O:10])[O:7][C:5]1=[O:6])[CH:2]=[CH2:3].[Cl:11][C:12]1[CH:13]=[C:14]([CH:16]=[C:17]([Cl:19])[CH:18]=1)[NH2:15].C(N(CC)CC)C.C1(C)C(C)=CC=CC=1>O>[Cl:11][C:12]1[CH:13]=[C:14]([N:15]=[C:5]([OH:6])[CH:4]([CH2:1][CH:2]=[CH2:3])[CH2:9][C:8]([OH:7])=[O:10])[CH:16]=[C:17]([Cl:19])[CH:18]=1

参加物

6

反応物 4

HCID 7237O-XyleneHCID 8471TriethylamineHCID 122813,5-DichloroanilineHCID 1110093-Allyl(dihydro)furan-2,5-dione

生成物 1

HCID 178445521HCID 178445521、化合物収率 89.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

28 g (0.2 moles) of allylsuccinic acid anhydride, 32.4 g (0.2 moles) of 3,5-dichloroaniline, 0.6 g of triethylamine and 150 ml of xylene are reacted at 125° C., with stirring. The water produced during the reaction is removed azeotropically by way of a water separator. The duration of the reaction is 4 hours. The solvent is subsequently drawn off and the residue is recrystallized from ethyl acetate with the addition of active carbon. The product has a melting point of 121° C. The yield is 89.4% of the theoretical yield.

後処理

  1. customis removed azeotropically by way of a water separator
  2. customthe residue is recrystallized from ethyl acetate with the addition of active carbon

出典と根拠

ORDレコード
ord-452f7412772341d09a13f8125837d84f
出典データセット
uspto-grants-1983_07
特許番号
US04393220

関連ノート

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