HCID 12833268、化合物 → 1-(3'-Amino-4',6'-dimethylphenyl)azetidin-2-one

HRID 1074852ノート

反応式

HRID 1074852 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([N:12]2[CH2:15][CH2:14][C:13]2=[O:16])[C:7]([CH3:11])=[CH:8][C:9]=1[CH3:10])([O-])=O>CO.[Ni]>[NH2:1][C:4]1[CH:5]=[C:6]([N:12]2[CH2:15][CH2:14][C:13]2=[O:16])[C:7]([CH3:11])=[CH:8][C:9]=1[CH3:10]

参加物

4

反応物 1

HCID 12833268HCID 12833268、化合物

生成物 1

HCID 128332701-(3'-Amino-4',6'-dimethylphenyl)azetidin-2-one収率 90.4%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

21.2 g (0.0965 mol) of the 1-(3'-nitro-4',6'-dimethylphenyl)-azetidin-2-one obtained according to a) are hydrogenated in 210 ml of methanol with 2 g of Raney nickel at 30°-35° under normal pressure. The reaction solution is filtered and evaporated. Recrystallisation of the crude product from methanol gives 16.6 g (90%) of crystals having a melting point of 123°-124°.

後処理

  1. filtrationThe reaction solution is filtered
  2. customevaporated
  3. customRecrystallisation of the crude product from methanol

出典と根拠

ORDレコード
ord-3f11ea2e6cfc4a61bc338740ae7d96d3
出典データセット
uspto-grants-1983_07
特許番号
US04394156

反応ノート

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