Acetyl chloride → 1-p-Chlorophenyl-1-acetoxy-2-(1,2,4-triazol-1-yl)-ethane

HRID 1074897

反応式

HRID 1074897 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:15])[CH2:9][N:10]2[CH:14]=[N:13][CH:12]=[N:11]2)=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:23](Cl)(=[O:25])[CH3:24]>C(OCC)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([O:15][C:23](=[O:25])[CH3:24])[CH2:9][N:10]2[CH:14]=[N:13][CH:12]=[N:11]2)=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 5580621-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-ol

生成物 1

HCID 204952251-p-Chlorophenyl-1-acetoxy-2-(1,2,4-triazol-1-yl)-ethane

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

1-p-Chlorophenyl-2-(1,2,4-triazol-1-yl)-ethanol (2.24 g) and triethylamine (1.1 g) in dry diethyl ether (50 ml) were treated with acetyl chloride (0.8 g) in dry diethyl ether (5 ml) and the mixture was stirred for 3 hours at room temperature to give a white solid which was filtered off and washed with ether. The solvent was removed from the filtrate to give a brown oil. The oil was distilled to give the title compound as a semi-solid which could not be purified further.

後処理

  1. customto give a white solid which
  2. filtrationwas filtered off
  3. washwashed with ether
  4. customThe solvent was removed from the filtrate
  5. customto give a brown oil
  6. distillationThe oil was distilled

出典と根拠

ORDレコード
ord-3d309a90b0e34583a4249dc890aaa831
出典データセット
uspto-grants-1983_07
特許番号
US04394380

関連ノート

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