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4-Piperidinecarboxamide → N-benzylpiperidine-4-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Piperidinecarboxamide | HCID 3772 | — |
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | N-benzylpiperidine-4-carboxamide | HCID 3868064 | 35% |
反応手順
4-Piperidinecarboxamide (10.2 g, 78.0 mmol) in DMSO (10 mL) was treated with benzyl bromide (20.0 mL, 168 mmol). The mixture was diluted with EtOAc and washed with 1N aq. HCl, 5N aq. NaOH, dried over MgSO4, and concentrated to give 5.90 g (35%) of N-benzyl-4-piperidinecarboxamide. [1H]-NMR(CDCl3) consistent with structure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05723490 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-aad08f27e18e4070affc2570d3f9689b |
| 出典メモ | uspto-grants-1998_03 |