Sodium Cyanide → 3-Cyanomethyl-10,11-dihydro-11-oxodibenzo[b,f]thiepin

HRID 1075019ノート

反応式

HRID 1075019 の反応式
Br[CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[C:12](=[O:13])[CH2:11][C:10]3[CH:14]=[CH:15][CH:16]=[CH:17][C:9]=3[S:8][C:7]=2[CH:18]=1.[C-:19]#[N:20].[Na+]>CN(C)C=O>[C:19]([CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[C:12](=[O:13])[CH2:11][C:10]3[CH:14]=[CH:15][CH:16]=[CH:17][C:9]=3[S:8][C:7]=2[CH:18]=1)#[N:20]

参加物

4

反応物 2

HCID 8929Sodium CyanideHCID 202702683-Bromomethyl-10,11-dihydro-11-oxodibenzo[b,f]thiepin

生成物 1

HCID 202702303-Cyanomethyl-10,11-dihydro-11-oxodibenzo[b,f]thiepin

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Dissolve 6.4 gm. of the bromide of Step 2 in 75 cc. of dimethylformamide and add 2.95 gm. of sodium cyanide. Stir the mixture at room temperature for 1.5 hours. Dilute with 600 cc. of water and extract three times with ether. Wash the combined organics with water, dry and strip to a solid residue. Triturate in hexane and recover the solid by filtration.

後処理

  1. dissolutionDissolve 6.4 gm
  2. additionDilute with 600 cc
  3. extractionof water and extract three times with ether
  4. washWash the combined organics with water
  5. customdry
  6. customTriturate in hexane
  7. customrecover the solid
  8. filtrationby filtration

出典と根拠

ORDレコード
ord-acde7dea38374252aa002e970daa77bb
出典データセット
uspto-grants-1983_07
特許番号
US04394515

反応ノート

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