Benzyl Chloride → 1-Benzyl-5-fluoropyrimid-2-one

HRID 1075152

反応式

HRID 1075152 の反応式
[CH2:1](Cl)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[K].[F:10][C:11]1[CH:12]=[N:13][C:14](=[O:17])[NH:15][CH:16]=1>CN(C)C=O>[CH2:1]([N:15]1[CH:16]=[C:11]([F:10])[CH:12]=[N:13][C:14]1=[O:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 7503Benzyl ChlorideHCID 1014985-Fluoropyrimidin-2-oneHCID 5462222Potassium

生成物 1

HCID 136163371-Benzyl-5-fluoropyrimid-2-one収率 50%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Benzyl chloride (0.01 mol) was added to a stirred mixture of the potassium salt of 5-fluoropyrimid-2-one (0.007 mol) in dimethylformamide (40 ml) and the mixture stirred at room temperature until chromatography showed the reaction to be complete. The solvent was then evaporated at reduced presure (1 mm Hg) and the residue was extracted with chloroform (100 ml). The chloroform solution was washed with aqueous 2 N NaCH (2×3 ml) and with water (3 ml) before drying (MgSO4) and evaporation; yield 50%, m.p. 163° C. (ethyl actate). (Found: C, 64.69; H, 4.49. Calc. for C11H9FN2O: C, 64.70; H, 4.44).

後処理

  1. customthe reaction
  2. customThe solvent was then evaporated at reduced presure (1 mm Hg)
  3. extractionthe residue was extracted with chloroform (100 ml)
  4. washThe chloroform solution was washed with aqueous 2 N NaCH (2×3 ml) and with water (3 ml)
  5. custombefore drying
  6. custom(MgSO4) and evaporation

出典と根拠

ORDレコード
ord-d93c328bdab04733b4b8c1df95d2c388
出典データセット
uspto-grants-1983_07
特許番号
US04395406

関連ノート

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