Chloroacetic Acid → HCID 20494284、化合物

HRID 1075171ノート

反応式

HRID 1075171 の反応式
[CH3:1][S:2][C:3]1[C:8]([F:9])=[CH:7][NH:6][C:5](=[O:10])[N:4]=1.Cl[CH2:12][C:13]([OH:15])=[O:14]>[OH-].[K+]>[C:13]([CH2:12][N:6]1[CH:7]=[C:8]([F:9])[C:3]([S:2][CH3:1])=[N:4][C:5]1=[O:10])([OH:15])=[O:14]

参加物

4

反応物 2

HCID 300Chloroacetic AcidHCID 178503576HCID 178503576、化合物

生成物 1

HCID 20494284HCID 20494284、化合物収率 36%

試薬・触媒・溶媒 1

HCID 14797Potassium Hydroxide溶媒

実験手順

4-Methylthio-5-fluoropyrimid-2-one (0.01 mol) was added to 2 M potassium hydroxide solution (10 ml) and dissolved. Chloroacetic acid (0.01 mol) was then added and the reaction mixture heated under reflux for 60 min when the pH was close to neutral. Some precipitate was removed by filtration from the cold reaction mixture and the filtrate brought to pH 2 with HCl. The precipitated product was recrystallised from aqueous methanol; yield 36%, m.p. 244°-245° C.

後処理

  1. dissolutiondissolved
  2. temperaturethe reaction mixture heated
  3. temperatureunder reflux for 60 min when the pH
  4. customwas close to neutral
  5. customSome precipitate was removed by filtration from the cold reaction mixture
  6. customThe precipitated product was recrystallised from aqueous methanol

出典と根拠

ORDレコード
ord-eb152c87e3fd4b6ab693ea0ec91f96af
出典データセット
uspto-grants-1983_07
特許番号
US04395406

反応ノート

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