Methanol → (3-Chloropropyl)octadecyldimethylammonium bromide

HRID 1075405

反応式

HRID 1075405 の反応式
[CH3:1][N:2]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH3:3].[Br:22][CH2:23][CH2:24][CH2:25][Cl:26].CO>CC(CC)=O>[Br-:22].[Cl:26][CH2:25][CH2:24][CH2:23][N+:2]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])([CH3:1])[CH3:3]

参加物

5

反応物 3

HCID 887MethanolHCID 80061-Bromo-3-chloropropaneHCID 15365Dimethyloctadecylamine

生成物 1

HCID 11037795(3-Chloropropyl)octadecyldimethylammonium bromide

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

反応条件

温度
65 °C

実験手順

A 1000 mL, round-bottomed flask equipped with air condensers and a magnetic stirring plate was charged with N,N-dimethyloctadecylamine (301.0 grams, 1.01 moles), 1-bromo-3-chloropropane (1700 grams, 1.08 moles) and methanol (200 mL). The reaction was maintained at 65° C. for 18 hours. Solvent was removed by rotary evaporation under reduced pressure to yield clear oil. The oil was transferred to a beaker containing methylethylketone (250 mL) causing a white precipitate to form. Solid material was collected by vacuum filtration, resuspended in methylethylketone (250 mL) and collected by vacuum filtration an additional two times. The solid was placed in a vacuum oven at 30° C. overnight. Yield 274.9 grams (0.59 moles, 58%).

後処理

  1. customA 1000 mL, round-bottomed flask equipped with air condensers
  2. customSolvent was removed by rotary evaporation under reduced pressure
  3. customto yield clear oil
  4. customto form
  5. filtrationSolid material was collected by vacuum filtration
  6. filtrationcollected by vacuum filtration an additional two times

出典と根拠

ORDレコード
ord-e0bd1728d4704a6d8a1cf97aa5c12e2b
出典データセット
uspto-grants-1999_05
特許番号
US05900475

関連ノート

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