Phosphorus tribromide → 4,6-Dimethyl-3-bromobenzofuran

反応式

[CH3:1][C:2]1[C:7]2[C:8](=O)[CH2:9][O:10][C:6]=2[CH:5]=[C:4]([CH3:12])[CH:3]=1.P(Br)(Br)[Br:14]>>[CH3:1][C:2]1[C:7]2[C:8]([Br:14])=[CH:9][O:10][C:6]=2[CH:5]=[C:4]([CH3:12])[CH:3]=1

参加物

反応物 2

HCID 24614Phosphorus tribromide

HCID 5955994,6-Dimethyl-3(2H)-benzofuranone

生成物 1

HCID 109002874,6-Dimethyl-3-bromobenzofuran収率 60%

反応条件

温度: 100 °C

実験手順

4,6-dimethyl-3-benzofuranone (0.09 moles) was slowly added in phosphorus tribromide (30 ml), previously heated to 100° C. The mix is cautiously treated with ice, extracted with methylenchloride. The organic phase is made anhydrous (Na2SO4) and freed from the solvent under reduced pressure to produce 4,6-dimethyl-3-bromobenzofuran (60% yield).

後処理

additionThe mix is cautiously treated with ice
extractionextracted with methylenchloride

出典と根拠

ORDレコード: ord-8d18552f4f4f43489256e82c32618c07
出典データセット: uspto-grants-1999_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05907045

反応ノート

読み込み中…

参加物