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Hydrochloric Acid → N-(5-Hydroxy-6-sulfamoylnaphthalen-1-yl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Chloroform | HCID 6212 | — |
| 反応物 | 2-Naphthalenesulfonyl chloride, 5-(acetylamino)-1-(acetyloxy)- | HCID 94125 | — |
| 反応物 | Ammonium Carbonate | HCID 517111 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-(5-Hydroxy-6-sulfamoylnaphthalen-1-yl)acetamide | HCID 21486282 | — |
反応手順
The 5-acetamido-1-hydroxynaphthalene-2-sulfonamide was prepared by dissolving 10.8 g. of 5-acetamido-1-acetoxynaphthalene-2-sulfonyl chloride in 10 ml. dry chloroform and heating on the steam bath with 25.0 g. anhydrous ammonium carbonate for 2.5 hours. The yellow-brown solid was dissolved by heating with 50 ml. water on the steam bath for 4 hours. Acidification with dilute hydrochloric acid to pH 5 caused the sulfonamide to precipitate. It was filtered off, washed and dried, yielding 5.61 g. (63%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03954476 |
| 出典データセット | uspto-grants-1976_05 |
| ORD ID | ord-83fc837e3e654b71a49d146611ae2a8d |
| 出典メモ | uspto-grants-1976_05 |