反応式
[C:1]([NH2:5])(=[NH:4])[CH2:2][CH3:3].CO[CH:8]=[C:9]([CH2:12][NH:13][CH:14]=[O:15])[C:10]#[N:11]>C(O)C>[CH2:2]([C:1]1[N:5]=[C:10]([NH2:11])[C:9]([CH2:12][NH:13][CH:14]=[O:15])=[CH:8][N:4]=1)[CH3:3]参加物
4
反応条件
- 温度
- 25 °C
実験手順
In 50 parts by volume of ethanol is dissolved 14 parts of α-methoxymethylene-β-formylaminopropionitrile. To the solution is added 100 parts by volume of an ethanol solution containing 17 parts of propioamidine. The mixture is reacted at 30°C for 0.5 hour. After the reaction, ethanol is distilled off and the residue is cooled at 25°C, whereby 18 parts of 2-ethyl-4-amino-5-formylaminomethylpyrimidine is obtained as crystals. (Yield: 100 %). Recrystallization of the crystals from benzene-ethanol mixture gives colorless crystals melting at 185°C.
後処理
- customThe mixture is reacted at 30°C for 0.5 hour
- distillationis distilled off
出典と根拠
- ORDレコード
- ord-a84e57b730254675a6ed4814c194a5b9
- 出典データセット
- uspto-grants-1976_05
- 特許番号
- US03954756
関連ノート
読み込み中…