Methanesulfonamide → 5-Bromo-N-methanesulfonylpentanamide

HRID 1075845

反応式

HRID 1075845 の反応式
[CH3:1][S:2]([NH2:5])(=[O:4])=[O:3].[Br:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11](Cl)=[O:12]>C(OCC)(=O)C>[CH3:1][S:2]([NH:5][C:11](=[O:12])[CH2:10][CH2:9][CH2:8][CH2:7][Br:6])(=[O:4])=[O:3]

参加物

4

反応物 2

HCID 72879MethanesulfonamideHCID 5211735-Bromovaleryl chloride

生成物 1

HCID 202961415-Bromo-N-methanesulfonylpentanamide収率 74.8%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 23.5 g. (0.25 mole) of methanesulfonamide and 49.8 g. (0.25 mole) of 5-bromovaleric acid chloride was heated at 80-85° (oil bath) for 45 minutes. The brown reaction mixture was allowed to cool and was dissolved in ethyl acetate. The organic solution was washed with water and saturated brine, was dried (anhydrous magnesium sulfate), was Darcoed, concentrated, and cooled to afford the white, crystalline N-methanesulfonyl-5-bromovaleramide weighing 48.2 g. (74.8% yield) which melted at 97°-98°.

後処理

  1. additionA mixture of 23.5 g
  2. temperatureto cool
  3. washThe organic solution was washed with water and saturated brine
  4. dry with materialwas dried (anhydrous magnesium sulfate)
  5. concentrationconcentrated
  6. temperaturecooled

出典と根拠

ORDレコード
ord-0eff3f6cdbf943e0a306fa9c72ffb88a
出典データセット
uspto-grants-1976_05
特許番号
US03954741

関連ノート

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