Methanesulfonamide → 5-Bromo-N-methanesulfonylpentanamide
反応式
[CH3:1][S:2]([NH2:5])(=[O:4])=[O:3].[Br:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11](Cl)=[O:12]>C(OCC)(=O)C>[CH3:1][S:2]([NH:5][C:11](=[O:12])[CH2:10][CH2:9][CH2:8][CH2:7][Br:6])(=[O:4])=[O:3]参加物
4
実験手順
A mixture of 23.5 g. (0.25 mole) of methanesulfonamide and 49.8 g. (0.25 mole) of 5-bromovaleric acid chloride was heated at 80-85° (oil bath) for 45 minutes. The brown reaction mixture was allowed to cool and was dissolved in ethyl acetate. The organic solution was washed with water and saturated brine, was dried (anhydrous magnesium sulfate), was Darcoed, concentrated, and cooled to afford the white, crystalline N-methanesulfonyl-5-bromovaleramide weighing 48.2 g. (74.8% yield) which melted at 97°-98°.
後処理
- additionA mixture of 23.5 g
- temperatureto cool
- washThe organic solution was washed with water and saturated brine
- dry with materialwas dried (anhydrous magnesium sulfate)
- concentrationconcentrated
- temperaturecooled
出典と根拠
- ORDレコード
- ord-0eff3f6cdbf943e0a306fa9c72ffb88a
- 出典データセット
- uspto-grants-1976_05
- 特許番号
- US03954741
反応ノート
読み込み中…