Nanofin → HCID 13277417、化合物
反応式
[Cl:1][CH2:2][CH:3]([OH:18])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:12][C:13]1[S:14][CH:15]=[CH:16][CH:17]=1.[CH3:19][CH:20]1[CH2:25][CH2:24][CH2:23][CH:22]([CH3:26])[NH:21]1>C(O)C>[ClH:1].[CH3:19][CH:20]1[CH2:25][CH2:24][CH2:23][CH:22]([CH3:26])[N:21]1[CH2:2][CH:3]([OH:18])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:12][C:13]1[S:14][CH:15]=[CH:16][CH:17]=1参加物
4
実験手順
A solution of 2.8 g of 1-chloro-3[2-(2-thienylmethyl)phenoxy]-2-propanol, 2.3 g of 2,6-dimethylpiperidine in 30 ml of ethanol is refluxed for 15 hours. The ethanol is then removed, and the residue is dissolved in ether. The insoluble matter is filtered off, and the filtrated is extracted with two 50 ml portions of 10% hydrochloric acid. The aqueous layer is made alkaline with sodium hydroxide, and separated oil is extracted with ether. The ether layer is dried over anhydrous potassium carbonate, and the solvent is removed. The residue (crude product) is purified by column chromatography and converted into the hydrochloride in the same manner as in above method (a) to give 2.1 g of 1-(2,6-dimethylpiperidino)-3-[2-(2-thienylmethyl)phenoxy]-2-propanol hydrochloride as colorless crystals, melting at 152°-153°C.