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Benzene → 1-Methyl-4-isopropyl-2-(3'-oxobutyl)-cyclohexan-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzene | HCID 241 | — |
| 反応物 | Methyl vinyl ketone | HCID 6570 | — |
| 反応物 | Menthone | HCID 26447 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1-Methyl-4-isopropyl-2-(3'-oxobutyl)-cyclohexan-3-one | HCID 14137252 | — |
反応手順
A mixture of 19.6 g of the pyrrolidine-enamine of p-menthone, 10 ml of methylvinyl ketone and 150 ml of anhydrous benzene is refluxed under nitrogen for 20 hours. The mixture is then cooled and treated with 6 g of sodium acetate in 12 ml of water as well as with 12 ml of acetic acid. The mixture is again refluxed for 4 hours. Then, the product is extracted with benzene and the solvent evaporated. The residue is fractionated in vacuo and there is obtained 1-methyl-4-isopropyl-2-(3'-oxobutyl)-cyclohexan-3-one with a boiling point of 88°-90°C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03954794 |
| 出典データセット | uspto-grants-1976_05 |
| ORD ID | ord-dbcb3ab2762a4a3b8b44db6097bd1fa6 |
| 出典メモ | uspto-grants-1976_05 |