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Triethylamine → Benzyl piperidine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Benzyl chloroformate | HCID 10387 | — |
| 反応物 | Piperidin-4-ol | HCID 79341 | — |
| 反応物 | Chloroform methanol | HCID 21584188 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Benzyl piperidine-1-carboxylate | HCID 228749 | 59.2% |
反応手順
4-Hydroxypiperidine (10.8 g, 107 mmol) and Et3N (17 mL, 123 mmol) in 80 mL of CH2Cl2 was cooled in an ice bath whereupon benzyl chloroformate (16.3 mL, 114 mmol) was added. After stirring 1.5 h at R.T. the mixture was subjected to standard work-up conditions to give 13.9 g (55%) of N-Cbz-piperidine after chromatography (CHCl3 /MeOH; 10:1). [1H]-NMR(CDCl3) consistent with structure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05723490 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-554bd9dd465641989667d60605d8d5a8 |
| 出典メモ | uspto-grants-1998_03 |