Hydrochloric Acid → HCID 21541490、化合物

HRID 1076013ノート

反応式

HRID 1076013 の反応式
[C:1]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[C:12](=[O:19])[CH2:13][CH:14]([OH:18])[C:15]=1[C:16]#[N:17])([O:3][CH3:4])=[O:2].Cl>[Zn].C(O)(=O)C>[C:1]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH:11]1[CH:15]([C:16]#[N:17])[CH:14]([OH:18])[CH2:13][C:12]1=[O:19])([O:3][CH3:4])=[O:2]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 21541510HCID 21541510、化合物

生成物 1

HCID 21541490HCID 21541490、化合物収率 63.8%

試薬・触媒・溶媒 2

HCID 23994Zinc触媒HCID 176Acetic Acid溶媒

実験手順

Into a mixture of 7 g of 2-(6'-carbomethoxyhexyl)-3-cyano-4-hydroxy-2-cyclopenten-1-one, 52.5 ml of acetic acid and 55 ml of 0.5 N hydrochloric acid was added 15 g of zinc powder. After the addition the reaction mixture was stirred for 3 hours under cooling. Thereafter, the zinc powder was removed by filtration, and the filtrate was diluted with water and extracted with ether. The ether extract was washed with a diluted aqueous sodium bicarbonate solution and with water and then dried. The solvent was distilled off to afford 4.5 g of 2-(6'-carbomethoxyhexyl)-3-cyano-4-hydroxy-cyclopentanone.

後処理

  1. additionAfter the addition the reaction mixture
  2. temperatureunder cooling
  3. customThereafter, the zinc powder was removed by filtration
  4. additionthe filtrate was diluted with water
  5. extractionextracted with ether
  6. extractionThe ether extract
  7. washwas washed with a diluted aqueous sodium bicarbonate solution and with water
  8. customdried
  9. distillationThe solvent was distilled off

出典と根拠

ORDレコード
ord-a4da38e28eef44e5b7f9a511cb9e1918
出典データセット
uspto-grants-1976_05
特許番号
US03954811

反応ノート

読み込み中…