Acetaldehyde → Phenyl[1-(piperidinosulfonylamino)ethyl]phenylphosphinate

HRID 1076096

反応式

HRID 1076096 の反応式
[C:1]1([P:7]([O:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[O:8]C2C=CC=CC=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:22](=O)[CH3:23].[N:25]1([S:31]([NH2:34])(=[O:33])=[O:32])[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1>ClC1C=CC=CC=1>[C:16]1([O:15][P:7]([CH:22]([NH:34][S:31]([N:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)(=[O:33])=[O:32])[CH3:23])([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[O:8])[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

参加物

5

反応物 3

HCID 177AcetaldehydeHCID 239038Diphenyl phenylphosphoniteHCID 2767411-Piperidinesulfonamide

生成物 1

HCID 21428537Phenyl[1-(piperidinosulfonylamino)ethyl]phenylphosphinate収率 75%

試薬・触媒・溶媒 1

HCID 7964Chlorobenzene溶媒

実験手順

This compound is obtained in 75% yield in a crude form from a mixture of equimolar quantities of diphenyl phenylphosphonite, acetaldehyde, and piperidinosulfonylamine in chlorobenzene. Recrystallization of a portion twice from acetonitrile gives a white solid product: mp 152°-165°; 31 p nmr(DMSO-d6) -38.4 ppm.

後処理

  1. customThis compound is obtained in 75% yield in a crude form
  2. customRecrystallization of a portion twice from acetonitrile
  3. customgives a white solid product

出典と根拠

ORDレコード
ord-06bba0584cd7458b826805a1f7445788
出典データセット
uspto-grants-1976_05
特許番号
US03954860

関連ノート

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