Triethylamine → HCID 21539424、化合物

HRID 1076198ノート

反応式

HRID 1076198 の反応式
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:9]([CH3:12])([CH3:11])[CH3:10])[C:6]=1[C:7]#[N:8].[CH3:13][N:14]=[C:15]=[O:16].C(N(CC)CC)C>CN(C)C=O>[C:7]([C:6]1[C:5]([C:9]([CH3:12])([CH3:11])[CH3:10])=[CH:4][S:3][C:2]=1[NH:1][C:15]([NH:14][CH3:13])=[O:16])#[N:8]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 5968662-Amino-4-(1,1-dimethylethyl)-3-thiophenecarbonitrile

生成物 1

HCID 21539424HCID 21539424、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of 4 g 2-amino-3-cyano-4-t-butylthiophene, 1.27 g methyl isocyanate and 3 ml triethylamine in 20 ml dimethylformamide was heated at 130°C. for 3 hours and then allowed to stand at about 25°C. overnight. The dimethylformamide was removed by distillation and the residue was crystallized from ether to give the product, as a tan solid, m.p. 212°-214°C. The infrared spectrum of the product showed cyano absorption at 4.6 microns. Sulfur analysis for the product is tabulated in Table I.

後処理

  1. customThe dimethylformamide was removed by distillation
  2. customthe residue was crystallized from ether
  3. customto give the product
  4. customcyano absorption at 4.6 microns

出典と根拠

ORDレコード
ord-29fe9d9ff3f94f46a5d89010d05c1bce
出典データセット
uspto-grants-1976_05
特許番号
US03956315

反応ノート

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