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Toluene → 4p-Chlorophenyl-5-methyl-2-pyrrolidinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | Nitroethane | HCID 6587 | — |
| 反応物 | Benzyltrimethylammonium hydroxide | HCID 66854 | — |
| 反応物 | 2-Propenoic acid, 3-(4-chlorophenyl)-, ethyl ester | HCID 201471 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4p-Chlorophenyl-5-methyl-2-pyrrolidinone | HCID 12395318 | — |
反応手順
A mixture of 150 g. (2 mole) of nitroethane, 105 g. (0.5 mole) of ethyl-p-chlorocinnamate and 6.6 g. of Triton B (a 35% solution of trimethyl-benzyl-ammonium hydroxide in methanol) is heated for 20 hours at 80°C. After the reaction has finished, toluene is added, washing is carried out with a saturated solution of sodium chloride and the organic solution is dried and evaporated to dryness and the residue is distilled. Yield: 80%; B.P.: 150°-155°C./0.3 mm.Hg.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03956314 |
| 出典データセット | uspto-grants-1976_05 |
| ORD ID | ord-faaf505d44704321a69020ba2cb9a13a |
| 出典メモ | uspto-grants-1976_05 |