Ethanol → 5-Benzyl-3-(chloromethyl)-1,2,4-oxadiazole

HRID 1076352ノート

反応式

HRID 1076352 の反応式
[Cl:1][CH2:2][C:3](=[N:5][OH:6])[NH2:4].Cl.[C:8]1(N=CC(OCC)=O)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[CH2:21](O)[CH3:22]>>[Cl:1][CH2:2][C:3]1[N:4]=[C:21]([CH2:22][C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[O:6][N:5]=1

参加物

4

反応物 3

HCID 702EthanolHCID 41122522-chloro-N'-hydroxyethanimidamideHCID 21540475Ethyl phenyliminoacetate hydrochloride

生成物 1

HCID 120442135-Benzyl-3-(chloromethyl)-1,2,4-oxadiazole

実験手順

A mixture of chloroacetamide oxime, 11.0 g. (0.10 mole), and ethyl phenyliminoacetate hydrochloride, 22 g. (0.11 mole), in 80 ml. of absolute ethanol is refluxed for one hour. After cooling, the ammonium chloride which precipitates is filtered off and the alcohol is removed in vacuo. Upon steam distillation of the residue, 7.0 gm. of 3-chloromethyl-5-benzyl-1,2,4-oxadiazole is obtained, n20 1.5386.

後処理

  1. temperatureAfter cooling
  2. customthe ammonium chloride which precipitates
  3. filtrationis filtered off
  4. customthe alcohol is removed in vacuo
  5. distillationUpon steam distillation of the residue, 7.0 gm

出典と根拠

ORDレコード
ord-c563bab3674c40f2bb308f1a8f37b253
出典データセット
uspto-grants-1976_05
特許番号
US03956498

反応ノート

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