Z-Thr(tbu)-ome → (2S,3R)-Methyl 2-amino-3-(tert-butoxy)butanoate

HRID 1076407ノート

反応式

HRID 1076407 の反応式
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:10]([O:12][CH3:13])=[O:11])[C@@H:3]([CH3:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6].[H][H]>C(O)(=O)C.[Pd].C>[NH2:1][C@H:2]([C:10]([O:12][CH3:13])=[O:11])[C@@H:3]([CH3:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6]

参加物

5

反応物 2

HCID 59113197Z-Thr(tbu)-omeHCID 178418361HCID 178418361、化合物

生成物 1

HCID 7018834(2S,3R)-Methyl 2-amino-3-(tert-butoxy)butanoate

試薬・触媒・溶媒 2

HCID 14818447Palladiumcarbon触媒HCID 176Acetic Acid溶媒

実験手順

12.92 g (40mmols) of Z-Thr(tBu)-OMe are hydrogenated in 200 ml of glacial acetic acid and 3 g of Pd-charcoal (10%) at room temperature. The hydrogen uptake is finished after 1 hour. The solution is freed of the catalyst by filtration and is evaporated in a waterpump vacuum at 35°C. After drying in a high vacuum at 35°C 7.3 g of an oil result, which according to a thin layer chromatogram is a single substance and is directly further used.

後処理

  1. customat room temperature
  2. filtrationThe solution is freed of the catalyst by filtration
  3. customis evaporated in a waterpump vacuum at 35°C
  4. dry with materialAfter drying in a high vacuum at 35°C 7.3 g of an oil
  5. customresult

出典と根拠

ORDレコード
ord-a926c3cb1a0d459da1056122b7103c2a
出典データセット
uspto-grants-1976_05
特許番号
US03956260

反応ノート

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