Ethanol → HCID 21537861、化合物

反応式

C([N:3]([CH2:6][CH3:7])[CH2:4][CH3:5])C.[CH:8]1([C:11]([N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)=[CH2:12])[CH2:10][CH2:9]1.C(Cl)(=O)C1C=C[N:22]=[CH:21][CH:20]=1.C([OH:29])C>>[CH:8]1([C:11]2([N:13]3[CH2:17][CH2:16][CH2:15][CH2:14]3)[O:29][N:22]=[C:21]([C:20]3[CH:5]=[CH:4][N:3]=[CH:6][CH:7]=3)[CH2:12]2)[CH2:10][CH2:9]1

参加物

反応物 4

HCID 702Ethanol

HCID 8471Triethylamine

HCID 417436Pyridine-4-carbonyl chloride

HCID 21537869HCID 21537869、化合物

生成物 1

HCID 21537861HCID 21537861、化合物

実験手順

To a stirred solution of 60 g. of triethylamine and 88 g. of 1-(1-cyclopropylvinyl)-pyrrolidine in 750 ml. of ethanol is added 40.5 g. of isonicotinoyl chloride, oxime hydrochloride in small portions during 100 minutes at room temperature. The ethanol is evaporated under reduced pressure and the oily residue is mixed with water. The aqueous mixture is extracted with ether, the ethereal solution dried over sodium sulfate and concentrated under reduced pressure to yield a brown solid, which is recrystallized from benzene-hexane to furnish straw-colored crystals, melting point 80°-85°C.