Iodoethane → HCID 21538594、化合物

HRID 1076827

反応式

HRID 1076827 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[NH:5][C:4](=[O:9])[CH:3]=1.[OH-].[K+].[CH2:12](I)[CH3:13]>C(O)C>[CH2:12]([N:5]1[C:6]([CH3:8])=[CH:7][C:2]([CH3:1])=[CH:3][C:4]1=[O:9])[CH3:13]

参加物

5

反応物 3

HCID 6340IodoethaneHCID 14797Potassium HydroxideHCID 2262884,6-Dimethylpyridin-2-ol

生成物 1

HCID 21538594HCID 21538594、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 4,6-dimethyl2(1H)-pyridone (2.46 g., 0.02 moles), potassium hydroxide (1.58 g., 0.024 moles) and ethyl iodide (6.24 g., 0.04 moles) in 50 ml. ethanol is heated at reflux for 3 hours. The ethanol is removed under vacuum leaving a solid residue which is extracted with methylene chloride. The methylene chloride extracts are washed with 2.5 N sodium hydroxide, water, a saturated salt solution, and dried over sodium sulfate. Evaporation of the dried extracts affords 1-ethyl-4,6-dimethyl-2(1H)-pyridone as a pale yellow oil (1.5 g., 48%) which shows a single spot on thin layer chromatography.

後処理

  1. temperatureat reflux for 3 hours
  2. customThe ethanol is removed under vacuum
  3. customleaving a solid residue which
  4. extractionis extracted with methylene chloride
  5. washThe methylene chloride extracts are washed with 2.5 N sodium hydroxide, water
  6. dry with materiala saturated salt solution, and dried over sodium sulfate
  7. customEvaporation of the dried extracts

出典と根拠

ORDレコード
ord-0112d6e67f9b4b5baf238050d3548d48
出典データセット
uspto-grants-1976_05
特許番号
US03957997

関連ノート

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