Toluene → 5-Methoxy-2-[4-(2-chloroethoxy)anilino]benzothiazole

HRID 1076831

反応式

HRID 1076831 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[S:10][C:9](S(C)(=O)=O)=[N:8][C:7]=2[CH:15]=1.[Cl:16][CH2:17][CH2:18][O:19][C:20]1[CH:26]=[CH:25][C:23]([NH2:24])=[CH:22][CH:21]=1.C1(C)C=CC=CC=1>O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[S:10][C:9]([NH:24][C:23]3[CH:22]=[CH:21][C:20]([O:19][CH2:18][CH2:17][Cl:16])=[CH:26][CH:25]=3)=[N:8][C:7]=2[CH:15]=1

参加物

5

反応物 3

HCID 1140TolueneHCID 1196994-(2-Chloroethoxy)aniline2 回HCID 215385965-Methoxy-2-methylsulphonylbenzothiazole

生成物 1

HCID 215385995-Methoxy-2-[4-(2-chloroethoxy)anilino]benzothiazole

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 5-methoxy-2-methylsulphonylbenzothiazole (1,105 g.), 4-(2-chloroethoxy)aniline (780 g.) and toluene (5 liters) is boiled for 2 hours under reflux with simultaneous removal of water. A further quantity of 4-(2-chloroethoxy)aniline (156 g.) is then added and the mixture boiled under reflux for 4 hours. The mixture is cooled, the solid filtered off, washed with ethanol (about 3 liters) and dried to give 5-methoxy-2-[4-(2-chloroethoxy)anilino]benzothiazole m.p. 176°- 178°C.

後処理

  1. temperatureunder reflux for 4 hours
  2. temperatureThe mixture is cooled
  3. filtrationthe solid filtered off
  4. washwashed with ethanol (about 3 liters)
  5. customdried

出典と根拠

ORDレコード
ord-14321e5b384c4a38ab4355a3ded5816b
出典データセット
uspto-grants-1976_05
特許番号
US03957999

関連ノート

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