Hydrochloric Acid → 2,7-Bis(4-aminobutyryl)thioxanthene Dihydrochloride

HRID 1076898

反応式

HRID 1076898 の反応式
C1(=O)[N:5]([CH2:6][CH2:7][CH2:8][C:9]([C:11]2[CH:24]=[CH:23][C:22]3[S:21][C:20]4[C:15](=[CH:16][C:17]([C:25](=[O:40])[CH2:26][CH2:27][CH2:28][N:29]5C(=O)C6=CC=CC=C6C5=O)=[CH:18][CH:19]=4)[CH2:14][C:13]=3[CH:12]=2)=[O:10])C(=O)C2=CC=CC=C12.C1(=O)N(CCCC([Cl:57])=O)C(=O)C2=CC=CC=C12.C1C2CC3C(=CC=CC=3)SC=2C=CC=1.[ClH:78]>C(O)(=O)C>[ClH:57].[ClH:78].[NH2:29][CH2:28][CH2:27][CH2:26][C:25]([C:17]1[CH:18]=[CH:19][C:20]2[S:21][C:22]3[C:13](=[CH:12][C:11]([C:9](=[O:10])[CH2:8][CH2:7][CH2:6][NH2:5])=[CH:24][CH:23]=3)[CH2:14][C:15]=2[CH:16]=1)=[O:40]

参加物

6

反応物 4

HCID 313Hydrochloric Acid2 回HCID 67495ThioxantheneHCID 5948864-(1,3-Dioxoisoindolin-2-yl)butanoyl chlorideHCID 21538549HCID 21538549、化合物

生成物 1

HCID 215385232,7-Bis(4-aminobutyryl)thioxanthene Dihydrochloride

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

2,7-Bis(4-phthalimidobutyryl)thioxanthene, prepared from 4-phthalimidobutyryl chloride and thioxanthene by the method of S.S. Cheng et al., J. Med. Chem. 9, 945 (1966), is treated with hot glacial acetic acid after which concentrated HCl is added gradually with stirring. The mixture is heated to reflux for 24 hours with a constant stream of HCl gas passing through the mixture. The reaction mixture is stirred and refluxed for an additional 24 hours, cooled, and the product worked up in the usual manner.

後処理

  1. additionis added gradually
  2. temperatureThe mixture is heated
  3. stirringThe reaction mixture is stirred
  4. temperaturerefluxed for an additional 24 hours
  5. temperaturecooled

出典と根拠

ORDレコード
ord-32bbde71d22946ac9780e9de7f260c7f
出典データセット
uspto-grants-1976_05
特許番号
US03957988

関連ノート

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