Hydrochloric Acid → HCID 21538576、化合物

HRID 1076915

反応式

HRID 1076915 の反応式
C1(=O)[N:5]([CH2:6][CH2:7][CH2:8][C:9]([C:11]2[CH:24]=[CH:23][C:22]3[O:21][C:20]4[C:15](=[CH:16][C:17]([C:25](=[O:40])[CH2:26][CH2:27][CH2:28][N:29]5C(=O)C6=CC=CC=C6C5=O)=[CH:18][CH:19]=4)[CH2:14][C:13]=3[CH:12]=2)=[O:10])C(=O)C2=CC=CC=C12.C1(=O)N(CCCC([Cl:57])=O)C(=O)C2=CC=CC=C12.C1C2CC3C(=CC=CC=3)OC=2C=CC=1.[ClH:78]>C(O)(=O)C>[ClH:57].[ClH:78].[NH2:29][CH2:28][CH2:27][CH2:26][C:25]([C:17]1[CH:18]=[CH:19][C:20]2[O:21][C:22]3[C:13](=[CH:12][C:11]([C:9](=[O:10])[CH2:8][CH2:7][CH2:6][NH2:5])=[CH:24][CH:23]=3)[CH2:14][C:15]=2[CH:16]=1)=[O:40]

参加物

6

反応物 4

HCID 313Hydrochloric Acid2 回HCID 7107XantheneHCID 5948864-(1,3-Dioxoisoindolin-2-yl)butanoyl chlorideHCID 21538574HCID 21538574、化合物

生成物 1

HCID 21538576HCID 21538576、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

2,7-Bis(4-phthalimidobutyryl)xanthene, prepared from 4-phthalimidobutyryl chloride and xanthene by the method of S. S. Cheng et al., J. Med. Chem. 9, 945 (1966), is treated with 700 ml. of hot glacial acetic acid after which 200 ml. of concentrated hydrochloric acid is added gradually with stirring. The mixture is heated to reflux for 24 hours with a constant stream of HCl gas passing through the mixture The reaction mixture is stirred and refluxed for an additional 24 hours, cooled, and the product worked up in the usual manner.

後処理

  1. addition9, 945 (1966), is treated with 700 ml
  2. temperatureThe mixture is heated
  3. stirringis stirred
  4. temperaturerefluxed for an additional 24 hours
  5. temperaturecooled

出典と根拠

ORDレコード
ord-48f747910c064377ac980362554069e3
出典データセット
uspto-grants-1976_05
特許番号
US03957989

関連ノート

読み込み中…