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Formaldehyde → N-[1-[(1,3-dihydro-1,3-dioxo-2H-benz[de]isoquinolin-2-yl)methyl]-4-piperidinyl]-N-phenylpropanamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | Naphthalimide | HCID 66491 | — |
| 反応物 | 4-(N-Propionylaniline)piperidine | HCID 259381 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N-[1-[(1,3-dihydro-1,3-dioxo-2H-benz[de]isoquinolin-2-yl)methyl]-4-piperidinyl]-N-phenylpropanamide | HCID 21535614 | — |
反応手順
An equimolar mixture of 4-(N-propionylanilino)piperidine, aqueous formaldehyde, and 1,8-naphthalimide is suspended in a small amount of dimethylformamide and the mixture is heated until dissolution is complete. The solution is allowed to stand at room temperature and the resulting precipitate is filtered off and dried to yield N-[1-[(1,3-dihydro-1,3-dioxo-2H-benz[de]isoquinolin-2-yl)methyl]-4-piperidinyl]-N-phenylpropanamide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03959286 |
| 出典データセット | uspto-grants-1976_05 |
| ORD ID | ord-fd5645c8b7274977960199a92827b267 |
| 出典メモ | uspto-grants-1976_05 |